A Landscape Cannot Be A Homeland

This is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this record.What is the problem for which landscape is the answer? In this paper, I offer a response to this question, first posed at a meeting of landscape researchers in Brussels in 2011. I argue that the problem can be defined as ontopology, or what I call here homeland thinking, and I propose that a landscape cannot be a homeland. The salience of landscape as a critical term instead involves modes of thinking and feeling that chafe against invocations of homeland as a site of existential inhabitation, as a locus of sentiment and attachment, and a wellspring of identity. The paper explores the connections between ideas of landscape and homeland through discussions of the European Landscape Convention, phenomenology and the term homeland itself. I conclude by arguing that a landscape must be understood as a kind of dislocation or distancing from itself. There are, after all, no original inhabitants

Investigating hookworm genomes by comparative analysis of two Ancylostoma species

Background Hookworms, infecting over one billion people, are the mostly closely related major human parasites to the model nematode Caenorhabditis elegans. Applying genomics techniques to these species, we analyzed 3,840 and 3,149 genes from Ancylostoma caninum and A. ceylanicum. Results Transcripts originated from libraries representing infective L3 larva, stimulated L3, arrested L3, and adults. Most genes are represented in single stages including abundant transcripts like hsp-20 in infective L3 and vit-3 in adults. Over 80% of the genes have homologs in C. elegans, and nearly 30% of these were with observable RNA interference phenotypes. Homologies were identified to nematode-specific and clade V specific gene families. To study the evolution of hookworm genes, 574 A. caninum / A. ceylanicum orthologs were identified, all of which were found to be under purifying selection with distribution ratios of nonsynonymous to synonymous amino acid substitutions similar to that reported for C. elegans / C. briggsae orthologs. The phylogenetic distance between A. caninum and A. ceylanicum is almost identical to that for C. elegans / C. briggsae. Conclusion The genes discovered should substantially accelerate research toward better understanding of the parasites' basic biology as well as new therapies including vaccines and novel anthelmintics

A statistical network analysis of the HIV/AIDS epidemics in Cuba

The Cuban contact-tracing detection system set up in 1986 allowed the reconstruction and analysis of the sexual network underlying the epidemic (5,389 vertices and 4,073 edges, giant component of 2,386 nodes and 3,168 edges), shedding light onto the spread of HIV and the role of contact-tracing. Clustering based on modularity optimization provides a better visualization and understanding of the network, in combination with the study of covariates. The graph has a globally low but heterogeneous density, with clusters of high intraconnectivity but low interconnectivity. Though descriptive, our results pave the way for incorporating structure when studying stochastic SIR epidemics spreading on social networks

The transcriptional profile of coronary arteritis in Kawasaki disease

BackgroundKawasaki Disease (KD) can cause potentially life-threatening coronary arteritis in young children, and has a likely infectious etiology. Transcriptome profiling is a powerful approach to investigate gene expression in diseased tissues. RNA sequencing of KD coronary arteries could elucidate the etiology and the host response, with the potential to improve KD diagnosis and/or treatment.MethodsDeep RNA sequencing was performed on KD (n = 8) and childhood control (n = 7) coronary artery tissues, revealing 1074 differentially expressed mRNAs. Non-human RNA sequences were subjected to a microbial discovery bioinformatics platform, and microbial sequences were analyzed by Metastats for association with KD.ResultsT lymphocyte activation, antigen presentation, immunoglobulin production, and type I interferon response were significantly upregulated in KD arteritis, while the tumor necrosis factor α pathway was not differentially expressed. Transcripts from known infectious agents were not specifically associated with KD coronary arteritis.ConclusionsThe immune transcriptional profile in KD coronary artery tissues has features of an antiviral immune response such as activated cytotoxic T lymphocyte and type I interferon-induced gene upregulation. These results provide new insights into the pathogenesis of KD arteritis that can guide selection of new immunomodulatory therapies for high-risk KD patients, and provide direction for future etiologic studies

Methods of asymptotic analysis in cavity quantum electrodynamics

The energy-level shift of a ground-state atom in front of a nondispersive dielectric half-space is calculated by quantizing the electric field by means of a normal-mode expansion and applying second-order perturbation theory to the electric-dipole Hamiltonian muE. It is shown that the contributions to this shift coming from traveling and from evanescent waves can be combined into a single expression which lends itself readily to asymptotic analysis for large atom-surface separations, while in the opposite asymptotic regime when the atom is close to the surface the combined expression is less convenient. Employing a Greens-function formalism instead of the normal-mode expansion leads directly to the combined formula, and in that case it is advantageous to be able to apply the same transformation backwards and split the energy shift into a sum of distinct contributions corresponding to different physical processes. The analysis serves to shed light on common sources of error in the literature and paves the way for the study of more complicated models in cavity quantum electrodynamics

An evaluation of early career academic nurses’ perceptions of a support program designed to build career-resilience

Early career academic nurses can struggle to meet the demands of career development due to feelings of being overwhelmed. Studies indicate that programs targeting these challenges are often sporadic and inconsistent, leading to dissatisfaction and missed opportunities. This paper reports on findings evaluating a program designed to build career-resilience in a group of early career academic nurses who, through the provision of a structured program of support, were enabled to succeed and thrive in the academy. This six session program was informed by Knowles’ adult learning theory, Mezirow’s transformational learning theory and Lord’s reliance on critical transactions. This study was undertaken in a large metropolitan university in Sydney, Australia. Participants included nine early career academic nurses. All had been full-time academics from one to six years. A qualitative descriptive design was employed using Braun and Clarke’s six stage process for data analyses. Three themes emerged: the program fostered connections, strengthened expertise and clarified directions. This analysis provided deep insights into the value of collegial relationships to galvanise career success. The program’s strength was its ability to lessen participants’ feelings of isolation and to develop behaviours that enhance career-resilience